Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The innate immune system and HIV pathogenesis.

Karla A Eger1, Derya Unutmaz

  • 1Department of Microbiology and Immunology, Vanderbilt University Medical School, 21st Avenue South, Medical Center North, Room AA-5206, Nashville, TN 37232-2363, USA.

Current HIV/AIDS Reports
|August 11, 2005
PubMed
Summary

Human immunodeficiency virus (HIV) disrupts the innate immune system, specifically impacting natural killer (NK) and natural killer T (NKT) cells, which are crucial for early infection defense.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.

Nature communications·2026
Same author

Editorial: Interdisciplinary innovations in CAR T-cell therapy for autoimmune and cancer treatment.

Frontiers in immunology·2026
Same author

Epidermal growth factor receptor regulates Beclin-1 in hyperoxic acute lung injury.

BMJ open respiratory research·2026
Same author

Roads and detours for CAR T cell therapy in autoimmune diseases.

Nature reviews. Drug discovery·2026
Same author

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.

bioRxiv : the preprint server for biology·2025
Same author

AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome.

Nature medicine·2025

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • Innate immunity is the body's initial defense against pathogens.
  • The innate immune system influences adaptive immunity.
  • Human immunodeficiency virus (HIV) is known to evade and disrupt immune responses.

Purpose of the Study:

  • To review how HIV perturbs innate immune system components.
  • To examine the disruption of natural killer (NK) and natural killer T (NKT) cells in HIV infection.

Main Methods:

  • Literature review of studies on HIV and innate immunity.
  • Analysis of the roles of NK and NKT cells in the context of HIV.

Main Results:

  • HIV directly targets and degrades adaptive immunity.

Related Experiment Videos

  • HIV also significantly perturbs components of the innate immune system.
  • Natural killer and natural killer T cells are identified as key disrupted innate lymphocyte subsets during HIV infection.

    • Conclusions:

    • HIV infection profoundly impacts both adaptive and innate immunity.
    • NK and NKT cells play a critical role in innate defense and are compromised by HIV.
    • Understanding these disruptions is vital for developing effective HIV therapies.