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70/30 insulin algorithm versus sliding scale insulin.

J Megan Schoeffler1, Dennis A K Rice, Douglas G Gresham

  • 1St. Joseph's/Candler Health System, Savannah, GA 31419-1791, USA.

The Annals of Pharmacotherapy
|August 11, 2005
PubMed
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A new 70/30 insulin algorithm significantly improved glycemic control in type 2 diabetes patients compared to traditional sliding scale insulin (SSI) dosing. This study highlights a more effective approach for managing blood glucose in hospitalized patients.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Internal Medicine

Background:

  • Sliding scale insulin (SSI) dosing is widely used but medically recognized as ineffective for blood glucose control.
  • A significant need exists for improved methods to manage hyperglycemia in clinical settings.
  • Type 2 diabetes management requires effective glycemic control strategies.

Purpose of the Study:

  • To evaluate the effectiveness of a 70/30 insulin algorithm versus traditional SSI for glycemic control.
  • To compare a novel insulin dosing strategy against standard care in hospitalized type 2 diabetes patients.

Main Methods:

  • A prospective, comparative cohort trial involving 20 patients with type 2 diabetes.
  • Patients were randomized to either a 70/30 insulin algorithm or traditional SSI regimen.

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  • Enrollment was based on pharmacy orders for SSI, with treatment allocation thereafter.

    • Main Results:

    • The 70/30 insulin algorithm group demonstrated superior glycemic control compared to the SSI group (p = 0.042).
    • No significant differences were observed in insulin units administered, injection frequency, or duration of therapy between the groups.
    • This pilot trial suggests a more effective insulin regimen for type 2 diabetes.

    Conclusions:

    • The 70/30 insulin algorithm offers superior glycemic control over traditional SSI dosing.
    • This algorithm presents a promising alternative for managing hyperglycemia in hospitalized patients with type 2 diabetes.