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Related Experiment Videos

Pineal region masses: differential diagnosis.

J G Smirniotopoulos1, E J Rushing, H Mena

  • 1Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|May 1, 1992
PubMed
Summary
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Most pineal region masses are malignant germ cell tumors in young males, commonly germinomas. Histologic verification is crucial as imaging patterns for these pineal tumors are often not definitive.

Area of Science:

  • Neuroradiology
  • Oncology
  • Pathology

Background:

  • Pineal region masses are frequently malignant germ cell neoplasms, predominantly affecting young males.
  • Germinomas are the most common type, presenting as homogeneous masses with gray matter-like characteristics, often engulfing calcified pineal glands.

Purpose of the Study:

  • To review the imaging characteristics of various pineal region masses.
  • To emphasize the diagnostic challenges and the necessity of histologic confirmation for neoplastic pineal masses.

Main Methods:

  • Review of imaging features (morphology, signal intensity, attenuation) of pineal region neoplasms.
  • Comparison of germ cell neoplasms with pineal parenchymal tumors.

Main Results:

Related Experiment Videos

  • Germinomas: homogeneous, gray matter-like signal, engulfing calcified pineal gland.
  • Teratomas: heterogeneous, multilocular masses with lipid components.
  • Pineal parenchymal neoplasms (pineocytomas, pineoblastomas): may disrupt calcifications, no sexual predilection, affect older patients.

Conclusions:

  • While imaging suggests diagnoses like germinoma or teratoma, few pineal region masses have pathognomonic patterns.
  • Histologic verification is essential for accurate diagnosis of most neoplastic pineal masses.