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Pediatric central nervous system posttransplant lymphoproliferative disorder
Kimberly C Brennan1, Lisa H Lowe, Gabrielle A Yeaney
1Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA. kimberly.brennan@vanderbilt.edu
AJNR. American Journal of Neuroradiology
|August 11, 2005
Summary
Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of renal transplants. This summary focuses on PTLD affecting the central nervous system, particularly in children, and its imaging findings.
Area of Science:
- Nephrology
- Oncology
- Neurology
Background:
- Post-transplant lymphoproliferative disorder (PTLD) affects approximately 1% of renal transplant recipients.
- PTLD commonly occurs in the abdomen, thorax, allograft, or head and neck regions.
Observation:
- Central nervous system (CNS) involvement in PTLD is infrequent.
- CNS PTLD often presents in isolation, without affecting other organ systems.
- Radiological literature has limited focus on acute and follow-up CNS findings of PTLD, especially in pediatric cases.
Findings:
- Imaging characteristics of CNS PTLD can mimic infections and primary CNS lymphoma.
- Early identification is crucial due to the poor prognosis of untreated CNS PTLD.
Implications:
- A high index of suspicion for CNS PTLD is essential in renal transplant patients.
- Prompt diagnosis and treatment of CNS PTLD can improve patient outcomes.
- Further research into pediatric CNS PTLD imaging is warranted.