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Transverse leukonychia: a case report.

V Modesto dos Santos1, T Arruda Modesto Sugai, B F Cezar

  • 1Catholic University and Armed Forces Hospital, Brasilia-DF. vitorinomodesto@ig.com.br

West African Journal of Medicine
|August 12, 2005
PubMed
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Chemotherapy for Hodgkin's disease can cause transverse leukonychia, appearing as white bands on fingernails. This nail change, also known as Muehrcke lines, is a cosmetic side effect and a potential indicator of prior cytotoxic therapy.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Hodgkin's disease is a cancer of the lymphatic system.
  • Chemotherapy is a common treatment for Hodgkin's disease, often involving cytotoxic agents.
  • Transverse leukonychia, or white nail banding, can be a side effect of various medical treatments.

Observation:

  • A 17-year-old male treated for Hodgkin's disease developed transverse leukonychia.
  • The white bands appeared on his fingernails three weeks post-chemotherapy.
  • The nail changes were uniform across the nail plates with smooth, rounded edges.

Findings:

  • The patient received a chemotherapy regimen including cyclophosphamide, adriamycin, procarbazine, prednisolone, vincristine, and bleomycin, along with mediastinal irradiation.

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  • The observed transverse leukonychia is consistent with Leukonychia striata or Muehrcke lines.
  • These nail changes are considered an aesthetic side effect.

    • Implications:

    • Transverse leukonychia can serve as a visible marker of prior cytotoxic therapy.
    • Monitoring nail changes may aid in identifying patients who have undergone chemotherapy.
    • This finding highlights the importance of recognizing dermatological side effects of cancer treatments.