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Functional daytime incontinence: pharmacological treatment
K Hjälmås1, G Passerini-Glazel, M L Chiozza
1Department of Paediatric Surgery, East Hospital, Gothenburg, Sweden.
Scandinavian Journal of Urology and Nephrology. Supplementum
|January 1, 1992
Summary
Bladder regimens are key for treating childhood daytime incontinence. A new drug, terodiline, significantly improved continence in children with urge incontinence compared to placebo.
Area of Science:
- Pediatric Urology
- Pharmacology
Background:
- Functional daytime incontinence in children often requires a bladder regimen focusing on timed voiding.
- Adjunctive drug therapy may be necessary for detrusor instability, but evidence for tricyclic antidepressants and anticholinergics is lacking.
Purpose of the Study:
- To evaluate the efficacy and safety of terodiline, a novel drug with anticholinergic and calcium-blocking properties, for treating functional daytime wetting in children.
Main Methods:
- Two randomized, double-blind, placebo-controlled studies were conducted.
- Children with urge incontinence (functional day wetting) received either terodiline or a placebo.
Main Results:
- Terodiline treatment resulted in a significant improvement in continence compared to placebo.
- Adverse reactions associated with terodiline were infrequent and mild.
- Chemotherapy is recommended for symptomatic urinary tract infections with day wetting, but asymptomatic bacteriuria should not be treated.
Conclusions:
- Terodiline demonstrates efficacy in improving daytime continence in children with urge incontinence.
- Treatment of asymptomatic bacteriuria is not recommended due to lack of benefit and risk of recurrence.