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Related Experiment Videos

Anti-C(w) alloimmunization presenting as hydrops fetalis.

Tanoj Gopalam Kollamparambil1, Bhavdeep Rameshchandra Jani, Maadh Aldouri

  • 1Department of Neonatology, Medway Maritime Hospital, Gillingham, Kent, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|August 12, 2005
PubMed
Summary
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Anti-C(w) alloimmunization is typically mild, but this case highlights a severe instance causing hydrops fetalis. Closer pregnancy monitoring is recommended for Rh blood group cases.

Area of Science:

  • Immunology
  • Hematology
  • Obstetrics

Background:

  • The C(w) antigen is a low-frequency red blood cell antigen within the Rh blood group system.
  • Anti-C(w) antibodies are usually naturally occurring and rarely cause significant hemolytic disease of the newborn (HDN).

Observation:

  • A case of anti-C(w) alloimmunization presented with significant fetal anemia and hydrops fetalis at 35 weeks gestation.
  • This presentation is atypical, as anti-C(w) is generally associated with mild or subclinical HDN.

Findings:

  • The alloimmunization led to severe fetal complications, including hydrops fetalis, contrary to typical presentations.
  • This case underscores the potential for severe outcomes even with antibodies usually considered low-risk.

Implications:

Related Experiment Videos

  • Pregnancies with anti-C(w) alloimmunization require increased surveillance.
  • More frequent antenatal ultrasound assessments are crucial for early detection of fetal hydrops.
  • Consideration of invasive procedures like cordocentesis and intrauterine transfusions may be necessary for affected pregnancies.