Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidative DNA modifications.

Henrik E Poulsen1

  • 1Department of Clinical Pharmacology Q7642, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. hepo@rh.dk

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie
|August 12, 2005
PubMed
Summary

Oxidative DNA damage is linked to cancer, diabetes, and aging. While evidence suggests a role, definitive proof and quantitative data on its human impact are still being gathered through ongoing studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association study and polygenic risk prediction of hypothyroidism.

Nature genetics·2025
Same author

Impact of non-participation bias due to psychiatric illness on mortality and cardiovascular event estimates: a Danish longitudinal population study.

BMJ public health·2025
Same author

Susceptibility to and severity of SARS-CoV-2 infection according to prescription drug use-an observational study of 46,506 Danish healthcare workers.

PloS one·2024
Same author

Hypothyroid women have persistently higher oxidative stress compared to healthy controls.

European thyroid journal·2023
Same author

Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans.

Aging cell·2023
Same author

Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials.

Free radical research·2023

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Oxidative DNA modifications are implicated in carcinogenesis, diabetes, and aging.
  • Evidence includes high lesion levels in cancer tissue and conserved repair systems.
  • Conflicting data exists regarding in vivo lesion occurrence and mutation induction.

Purpose of the Study:

  • To evaluate the evidence linking oxidative DNA modifications to cancer.
  • To discuss methodologies for measuring oxidative DNA damage.
  • To estimate the quantitative role of oxidative DNA damage in human health.

Main Methods:

  • Review of existing evidence from chemistry, clinical, and epidemiological trials.
  • Analysis of methodologies for measuring oxidative DNA modifications, including artifact prevention.
  • Interlaboratory standardization efforts for consistent measurement.

Main Results:

  • Disagreement on in vivo lesion levels and localization in critical genes.
  • Lack of direct evidence for lesion-induced mutations in vivo.
  • Established "normal" levels of 8-oxodG at approximately 5 per million dG.

Conclusions:

  • Oxidative DNA modifications exist and are repaired, but their quantitative role in human disease remains unclear.
  • Methodologies for measurement are complex and prone to artifacts, though standardization is improving.
  • Prospective human studies are needed to quantify the impact of oxidative DNA damage.

Related Experiment Videos