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Related Experiment Videos

Dissolution, solubility, XRD, and DSC studies on flurbiprofen-nicotinamide solid dispersions.

M M Varma1, J K Pandi

  • 1Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, India. mohan_pharm@rediffmail.com

Drug Development and Industrial Pharmacy
|August 12, 2005
PubMed
Summary

Flurbiprofen-nicotinamide solid dispersions significantly enhance flurbiprofen dissolution and aqueous solubility. These findings suggest improved drug delivery potential for flurbiprofen formulations.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) with poor aqueous solubility.
  • Enhancing drug solubility and dissolution rate is crucial for improving oral bioavailability.

Purpose of the Study:

  • To prepare and characterize flurbiprofen-nicotinamide solid dispersions.
  • To evaluate the impact of nicotinamide on flurbiprofen's dissolution rate and aqueous solubility.

Main Methods:

  • Fusion method for solid dispersion preparation.
  • Phase solubility analysis, phase diagrams, X-ray diffraction (XRD), and differential scanning calorimetry (DSC) for drug-carrier interaction studies.
  • Dissolution rate testing.

Main Results:

Related Experiment Videos

  • Flurbiprofen-nicotinamide solid dispersions exhibited significantly faster and more rapid dissolution compared to pure flurbiprofen and physical mixtures.
  • Phase diagrams and DSC confirmed the formation of a eutectic mixture between flurbiprofen and nicotinamide.
  • The presence of nicotinamide enhanced the aqueous solubility of flurbiprofen.

    • Conclusions:

    • Flurbiprofen-nicotinamide solid dispersions are an effective approach to improve flurbiprofen's dissolution rate and solubility.
    • The observed enhancement is attributed to the formation of a eutectic mixture and improved drug-carrier interactions.
    • This formulation strategy holds promise for developing more effective flurbiprofen delivery systems.