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Updated: Aug 16, 2026
Hyperpolarized Xenon for NMR and MRI Applications
Published on: September 6, 2012
Improvement of T1 determination of hyperpolarized 129Xe in mouse brain under controlled-flow
Atsuomi Kimura1, Tetsuya Wakayama, Michiko Narazaki
1Division of Medical Physics and Engineering, Area of Medical Technology and Science, Course of Health Science, Graduate School of Medicine, Osaka University, Suita, Japan. kimura@sahs.med.osaka-u.ac.jp
Abstract:
The method of determining the longitudinal relaxation time of hyperpolarized 129Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1+/-1.6 s as the relaxation time.
