Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomarkers in osteoarthritis.

Virginia Byers Kraus1

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. vbk@acpub.duke.edu

Current Opinion in Rheumatology
|August 12, 2005
PubMed
Summary

Recent advances in osteoarthritis biomarker research show promising developments. Emerging biomarkers are showing credible associations with disease modification, potentially improving therapeutic development and clinical care for osteoarthritis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune Biomarker Signatures as Predictors of Functional and Pain Recovery After Total Knee Arthroplasty in Older Adults.

medRxiv : the preprint server for health sciences·2026
Same author

RYR1<sup>+</sup> skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.

Journal of translational medicine·2026
Same author

Dipeptidyl peptidase-4 inhibitors are associated with a lower risk of osteoarthritis in patients with type 2 diabetes.

Therapeutic advances in musculoskeletal disease·2026
Same author

CSPG4<sup>+</sup> extracellular vesicles carry fibronectin and interleukin-11 and reflect radiographic severity in knee osteoarthritis.

Osteoarthritis and cartilage open·2026
Same author

Gut Microbiota Associated with Type 2 Diabetes and Dietary Balance in Older Adults: A Longitudinal Community-Based Cohort in China.

Diabetes, metabolic syndrome and obesity : targets and therapy·2026
Same author

The role of type I collagen fragment C1M in knee osteoarthritis. A longitudinal biomarker study using data from the OA-FNIH consortium.

Osteoarthritis and cartilage·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Clinical Trials

Background:

  • Osteoarthritis (OA) biomarker discovery and validation have advanced significantly.
  • Understanding of joint tissue molecules and their interactions is evolving.
  • There is a critical need for improved OA outcome measures in clinical trials.

Purpose of the Study:

  • To review recent advances in osteoarthritis-related biomarker research.
  • To highlight new approaches, biomarkers, and validation studies.
  • To assess the impact of biomarkers on disease modification and therapeutic development.

Main Methods:

  • Review of studies published within the past year on OA biomarkers.
  • Categorization of studies into new approaches/biomarkers, specialized subsets, validation studies, and longitudinal studies.
  • Analysis of biomarker associations with OA natural history and therapeutic interventions.

Main Results:

  • Studies explored new biochemical markers and approaches in OA.
  • Research included specialized disease subsets and large validation studies.
  • Longitudinal studies, with and without interventions, were also examined.

Conclusions:

  • Most studies focused on biomarker associations with OA natural history.
  • Several emerging biomarkers show credible associations with disease modification.
  • Expanding OA biomarker pool is expected to advance OA therapeutics and clinical care.

Related Experiment Videos