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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Predicting outcomes in renal cell carcinoma
Brian R Lane1, Michael W Kattan
1Glickman Urological Institute, The Cleveland Clinic Foundation, OH 44195, USA.
Purpose Of Review:
Renal cell carcinoma is estimated to account for more than 35,000 new diagnoses and more than 12,000 cancer-related deaths in the United States in 2005, making it the most lethal of genitourinary malignancies. Approximately 25% of patients with renal cell carcinoma present with metastases, and about a third of those treated surgically for localized renal cell carcinoma will develop a recurrence. Current therapeutic options for disseminated disease benefit only a small percentage of patients.
Recent Findings:
Many clinical, histologic, and molecular factors have been identified that place a patient at risk for recurrence. Several prognostic algorithms, or nomograms, for renal cell carcinoma survival or recurrence after nephrectomy have been developed that incorporate many of these factors.
Summary:
Renal cell carcinoma nomograms allow more accurate counseling of patients regarding their probable clinical course, facilitate treatment planning, and identify high-risk patients for experimental treatments.
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