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Updated: Jan 25, 2026

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Antisense oligonucleotide therapy in the management of bladder cancer

Alan So1, Palma Rocchi, Martin Gleave

  • 1The Prostate Centre at Vancouver General Hospital, University of British Columbia, Canada. aso@vanhosp.bc.ca

Current Opinion in Urology
|August 12, 2005
PubMed
Abstract

Insights

Antisense oligonucleotide therapy shows promise for superficial bladder cancer treatment. Recent advances in delivery and preclinical studies support its potential for clinical trials and effective intravesical therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Superficial bladder cancer presents unique opportunities for localized therapeutic interventions.
  • Antisense oligonucleotide (ASO) therapy offers a targeted molecular approach to cancer treatment.

Purpose of the Study:

  • To review recent advancements in antisense oligonucleotide therapy for superficial bladder cancer.
  • To explore the potential of ASO therapy as a treatment modality for bladder cancer.

Main Methods:

  • Review of recent preclinical in-vitro studies on antisense oligonucleotide therapy in bladder cancer cell lines.
  • Analysis of developments in antisense oligonucleotide delivery systems for intravesical administration.

Main Results:

  • Preclinical studies demonstrate the in-vitro effectiveness of antisense oligonucleotide therapy in various bladder cancer cell lines.
  • Advances in antisense oligonucleotide delivery enhance the potential for intravesical application.

Conclusions:

  • In-vitro and in-vivo preclinical data provide a strong rationale for advancing antisense oligonucleotide therapy into phase I clinical trials.
  • Antisense oligonucleotide technology represents a promising therapeutic strategy for superficial bladder cancer treatment.

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