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[Examination of the causative agent of pityriasis versicolor]

Nobuaki Morishita1, Yoshihiro Sei, Iwao Takiuchi

  • 1Department of Dermatology, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.

Nihon Ishinkin Gakkai Zasshi = Japanese Journal of Medical Mycology
|August 12, 2005
PubMed

Insights

Pityriasis versicolor (PV) is a skin infection caused by Malassezia yeast. This study suggests Malassezia globosa is the primary cause, detected in most patients using PCR.

Area of Science:

  • Mycology
  • Dermatology
  • Microbiology

Background:

  • Pityriasis versicolor (PV) is a superficial skin infection affecting the stratum corneum.
  • The genus Malassezia comprises eleven recognized species, implicated in various skin conditions.
  • Accurate identification of causative Malassezia species is crucial for understanding PV pathogenesis.

Purpose of the Study:

  • To investigate the distribution and prevalence of Malassezia species in patients diagnosed with pityriasis versicolor.
  • To differentiate between the yeast and mycelial forms of Malassezia in skin scrapings.
  • To identify the specific Malassezia species responsible for causing pityriasis versicolor.

Main Methods:

  • A non-culture-based method utilizing nested PCR with specific primers was employed.
  • Detection of Malassezia species was performed on skin samples from PV patients.
  • Microscopic examination of skin scales was conducted to observe yeast and mycelial forms.

Main Results:

  • Malassezia globosa and Malassezia restricta were the most frequently detected species, identified in 93.9% of patients.
  • Malassezia globosa was found in scales containing predominantly the mycelial form.
  • Malassezia restricta was not detected in its mycelial form, despite its high prevalence as yeast.

Conclusions:

  • The findings suggest Malassezia globosa is the primary etiological agent responsible for pityriasis versicolor.
  • The study highlights the utility of molecular methods like PCR for accurate fungal identification in skin infections.
  • Further research may elucidate the specific role of different Malassezia species and their morphological forms in PV development.

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