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Updated: Jul 14, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Colorectal cancer: mutations in a signalling pathway.

D Williams Parsons1, Tian-Li Wang, Yardena Samuels

  • 1The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

Nature
|August 12, 2005
PubMed
Summary

Researchers identified genetic mutations in serine/threonine kinases in human colorectal cancers. This discovery highlights the phosphatidylinositol-3-OH kinase (PI(3)K) pathway as a potential therapeutic target for cancer treatment.

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