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Updated: Aug 16, 2026
Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos
Published on: April 29, 2011
Expression of man, a formin homology domain-containing gene in the mouse limb
Yan-Zhen Cui1, Yi-Feng Peng, Qi Tian
1Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd., Beaverton, OR 97006, USA;Institute of Reproductive Medicine, Yijishan Hospital, Wannan Medical College, Wuhu 241001, China;Department of Pathology, L113, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA;E-mail: cuiy@ebs.ogi.edu.
Abstract:
Formin defines a family of structurally related proteins that have two formin homology domains (FH1 and FH2). Various mutations in the formin locus result in limb deformity, suggesting that these genes play indispensable roles in the limb development. Here we report the isolation of a novel cDNA, man, from the mouse limb, which contains two conserved FH1 and FH2 domains. Its expression is described and possible functional significance is discussed.
