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Drug targeting with nano-sized carrier systems
1Kanagawa Academy of Science and Technology, KSP East 404, Kawasaki, Kanagawa 213-0012, Japan. masajun@ksp.or.jp
Summary
This study reviews drug targeting via bloodstream, covering methods, carriers, and clinical uses. It explores connections between drug delivery systems, artificial organs, implants, and biomaterials for future perspectives.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Materials Science
Background:
- Drug delivery systems are crucial for effective therapeutics.
- Targeting drugs to specific sites minimizes systemic toxicity.
- Advancements in biomaterials and artificial organs offer new avenues for drug delivery.
Purpose of the Study:
- To provide a comprehensive overview of current drug targeting strategies.
- To discuss various drug carrier types and their clinical applications.
- To explore the interdisciplinary relationship between drug targeting and related biomedical fields.
Main Methods:
- Review of existing literature on drug targeting methodologies.
- Explanation of active and passive targeting strategies.
- Categorization and discussion of five main types of drug carriers.
Main Results:
- Detailed explanation of the magic bullet and enhanced permeability and retention (EPR) effect strategies.
- Clinical status assessment of five distinct drug carrier systems.
- Identification of correlations with artificial organs, implants, and biomaterials.
Conclusions:
- Drug targeting holds significant therapeutic potential.
- The development of novel drug carriers is essential for improved efficacy.
- Interdisciplinary research is key to advancing drug delivery systems.