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Related Experiment Videos

Biodegradable membrane-covered stent from chitosan-based polymers.

Benjamin Thierry1, Yahye Merhi, Jim Silver

  • 1Department of Biomedical Engineering, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada.

Journal of Biomedical Materials Research. Part A
|August 12, 2005
PubMed
Summary

This study developed a biodegradable chitosan-polyethylene oxide membrane-covered stent for vascular disease treatment. The optimized membrane demonstrated excellent mechanical strength, hemocompatibility, and potential for drug delivery, reducing platelet adhesion.

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Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Polymer Chemistry

Background:

  • Vascular diseases like aneurysms and fistulas require advanced treatment devices.
  • Embolic complications during saphenous vein graft revascularization are a clinical challenge.
  • Biodegradable membrane-covered stents offer a promising solution for vascular repair and disease management.

Purpose of the Study:

  • To design and develop a clinically applicable, biodegradable membrane-covered stent using chitosan.
  • To optimize the mechanical properties and hemocompatibility of the chitosan-based membrane.
  • To evaluate the potential of the membrane as a drug reservoir for enhanced therapeutic outcomes.

Main Methods:

  • Chitosan blended with polyethylene oxide (70:30% Wt CH:PEO) to create the membrane.

Related Experiment Videos

  • Mechanical testing to assess membrane performance during stent deployment and under physiological pressure.
  • Ex vivo hemocompatibility assays, including platelet adhesion studies with and without heparin/hyaluronan complexation.
  • Drug loading studies using sodium nitroprusside (SNP) to evaluate drug reservoir capacity and effect on platelet adhesion.

    • Main Results:

    • The CH-PEO membrane successfully sustained stent deployment deformation.
    • High burst pressure resistance (>500 mm Hg) and low water permeation (1 mL/cm(2) min(-1) at 120 mmHg) were achieved.
    • The membrane exhibited good hemocompatibility, with significant reduction in platelet adhesion upon heparin (50.1%) and hyaluronan (63%) complexation.
    • SNP-loaded membranes demonstrated significantly reduced platelet adhesion.

    Conclusions:

    • A clinically applicable biodegradable membrane-covered stent based on CH-PEO was successfully developed.
    • The optimized membrane possesses favorable mechanical properties and hemocompatibility for vascular applications.
    • The membrane serves as an effective drug reservoir, capable of reducing platelet adhesion when loaded with SNP, highlighting its therapeutic potential.