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Markers of endothelial cell activation in elderly men at high risk for coronary heart disease

E M Hjerkinn1, I Seljeflot, L Sandvik

  • 1Centre for Clinical Research, Ullevaal University Hospital, Oslo, Norway. elsa.hjerkinn@ulleval.no

Scandinavian Journal of Clinical and Laboratory Investigation
|August 13, 2005
PubMed

Insights

Elevated levels of circulating cell adhesion molecules (CAMS) like tissue-type plasminogen activator antigen (tPAag) are linked to cardiovascular disease (CVD). Smoking and diabetes also influence levels of these inflammatory markers.

Area of Science:

  • Biomarkers and Cardiovascular Health
  • Endothelial Function and Atherosclerosis
  • Hemostatic System Markers

Background:

  • Circulating cell adhesion molecules (CAMS) and hemostatic markers such as thrombomodulin (TM), von Willebrand factor (vWF), and tissue-type plasminogen activator antigen (tPAag) are recognized inflammatory indicators associated with atherosclerosis and cardiovascular disease (CVD).
  • Elevated levels of these markers are implicated in atherothrombotic cardiovascular disease states.

Purpose of the Study:

  • To investigate the relationship between circulating cell adhesion molecules (CAMS) and hemostatic markers with cardiovascular morbidity, diabetes, hypertension, and smoking habits.
  • To analyze the association of specific markers like tPAag, TM, vWF, sICAM-1, sVCAM-1, and sE-selectin with various clinical conditions.

Main Methods:

  • A cross-sectional study involving 563 hypercholesterolemic men aged 70 (range 64-76) years, with data collected in 1972 and followed up for 24 years.
  • Measurement of circulating markers including TM, vWF, tPAag, sICAM-1, sVCAM-1, and sE-selectin.
  • Statistical analysis including comparison between clinical groups and multivariate regression to identify significant associations.

Main Results:

  • Significantly higher tPAag levels were observed in patients with CVD (p=0.02).
  • Smokers exhibited higher sICAM-1 and lower sVCAM-1 and sTM levels compared to non-smokers (p<0.001, p=0.01, p<0.01 respectively).
  • Diabetics showed elevated sE-selectin and tPAag (p<0.001, p=0.001 respectively), while hypertensive subjects had higher TM levels (p=0.03).
  • Multivariate analysis confirmed associations of tPAag with CVD, sE-selectin with diabetes, sTM with hypertension, and sVCAM-1, sICAM-1, sTM with smoking.

Conclusions:

  • These findings highlight the influence of clinical factors such as CVD, diabetes, hypertension, and smoking on circulating endothelial and hemostatic markers.
  • The results contribute to understanding the complex interplay of factors affecting these markers in various disease states.
  • The study underscores the potential utility of these markers in evaluating endothelial function and risk in diverse patient populations.
Abstract

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