Isoagglutinins following ABO-incompatible bone marrow transplantation

Isoagglutinins were investigated following ABO-incompatible bone marrow transplantation. In major incompatibility anti-A tends to require more time to disappear than anti-B. Correspondingly, A erythrocytes require more time to become demonstrable. There is no such difference in major plus minor incompatibility. In minor incompatibility, isoagglutinins against the recipient blood group may be produced early after bone marrow transplantation, which then give way to a possibly lifelong tolerance for the recipient's old blood group.