Related Experiment Video
Updated: Aug 16, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Postpartum depression without delivering a child?
G Manfredi1, S Lazanio, G D Kotzalidis
1Department of Psychiatry, La Sapienza University of Rome - Sant'Andrea Hospital, Via di Grottarossa, Rome, Italy. giovanni.manfredi@uniroma1.it
Objective:
Depression in people related to delivering women is documented in their mates, but only anecdotal in other family members. We describe a case of depression in a woman who had previously experienced postpartum depression after the birth of her nephew.
Method:
A clinical description of the case.
Results:
A 53-year-old woman, hysterectomized at age 47 years, was admitted for attempted suicide. She developed major depressive episode 1 month after her daughter had delivered a son. She had a past history of two postpartum depressive episodes clinically identical to the current episode. The episode resolved after 5 weeks. At 1-year follow-up, the patient is still asymptomatic.
Conclusion:
Psychological and cultural factors were at play in this case more than hormonal and biopsychosocial ones.
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