Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A computer match program for paired and unconventional kidney exchanges.

Inessa Kaplan1, Julie A Houp, Robert A Montgomery

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ikaplan@jhmi.edu

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|August 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Physiology and immunology of a pig-to-human decedent kidney xenotransplant.

Nature·2026
Same author

Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy.

The New England journal of medicine·2026
Same author

Bridging monitoring gaps in global drylands with big data and collaboration.

npj biodiversity·2026
Same author

Contemporary Trends in Heart Failure Mortality: The Pandemic Ended, the Epidemic Continues.

JACC. Heart failure·2026
Same author

Hypothermic vs Normothermic Machine Perfusion in Liver Transplantation in the US: A Cohort Study.

Journal of the American College of Surgeons·2026
Same author

A highly sensitive issue: Helping sensitized patients requires greater regulatory flexibility.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Comment on "Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis".

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Ebola disease caused by Bundibugyo virus, Democratic Republic of the Congo & Uganda.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

Human Biopsy-Defined IRI-Selective Reperfusion Signature Prioritizes Reperfusion-Timed MEK Inhibition After DCD Liver Transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same journal

OPERATIONAL TOLERANCE FOLLOWING INTESTINAL TRANSPLANTATION: A CASE REPORT WITH COMPREHENSIVE IMMUNE FOLLOW-UP FROM TRANSPLANT DAY TO THREE YEARS POST-IMMUNOSUPPRESSION WITHDRAWAL.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
See all related articles

Kidney transplant exchanges can be optimized with advanced computer programs. These programs efficiently identify compatible donor-recipient pairs for multiple-way exchanges, increasing transplant numbers.

Area of Science:

  • Nephrology
  • Transplantation immunology
  • Computer science

Background:

  • Kidney transplantation is a vital treatment for end-stage renal disease.
  • Donor-recipient incompatibility, including ABO and HLA factors, limits transplant numbers.
  • Current exchange programs are often restricted to two-way exchanges and specific incompatibilities.

Purpose of the Study:

  • To develop a computational method for optimizing kidney exchange programs.
  • To increase the number of successful renal transplants through efficient matching.
  • To overcome limitations of traditional two-way and ABO-restricted exchanges.

Main Methods:

  • Development of a computer program to analyze ABO and HLA compatibility.
  • Inclusion of multi-way (three-way and beyond) donor-recipient exchanges.

Related Experiment Videos

  • Utilizing a database of 60 patients and 83 donors for testing.

    • Main Results:

    • The program identified 122 two-way exchanges.
    • The program identified 1230 three-way exchanges.
    • Average program run time was 30 seconds, demonstrating efficiency.

    Conclusions:

    • A sophisticated computer program can significantly enhance kidney exchange programs.
    • Multi-way exchanges, facilitated by computational analysis, substantially increase transplant opportunities.
    • The developed program efficiently manages complex compatibility data for improved donor-recipient matching.