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Updated: Aug 16, 2026

Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies
Published on: April 19, 2018
Molecular regulation of satellite cell function
Chet E Holterman1, Michael A Rudnicki
1Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada K1H 8L6.
Abstract:
Quiescent satellite cells are responsible for the repair of post-natal skeletal muscle. These cells are easily identified by their unique morphology within skeletal muscle as well as by several recently elucidated molecular markers. Careful examination of the function of these markers has provided insight into the early events surrounding satellite cell specification and activation. However, the origin of these cells, as well as the mechanisms by which this population is maintained within the adult remain elusive. Furthermore, the ability of non-muscle derived stem cells and the potential multipotency of satellite cells have altered the traditional views of skeletal muscle regeneration.
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