Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacogenetics in drug development.

Alun D McCarthy1, James L Kennedy, Lefkos T Middleton

  • 1Translational Medicine & Genetics, GlaxoSmithKline, Greenford Road, Greenford, Middlesex UB6 0HE, UK.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 13, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the association of anxiety disorders with heart rate variability measured using a wearable device.

Journal of affective disorders·2024
Same author

User Experiences of Pharmacogenomic Testing and Opinions among Psychiatry Patients.

Journal of personalized medicine·2024
Same author

Interplay between polygenic risk for mood disorders and stressful life events in bipolar disorder.

Journal of affective disorders·2024
Same author

<i>COMT</i> Val/Met, stressful life events and externalizing behaviors in youth: A longitudinal study from the ABCD sample.

Heliyon·2023
Same author

Heart rate variability: Evaluating a potential biomarker of anxiety disorders.

Psychophysiology·2023
Same author

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.

The American journal of psychiatry·2023
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Pharmacogenetics (PGx) uses genetic information to guide drug selection and therapy. Advances in genetic technologies are expanding PGx applications in drug discovery, development, and personalized medicine.

Area of Science:

  • Genetics and Genomics
  • Pharmacology
  • Personalized Medicine

Background:

  • Genetic polymorphisms influencing human diseases are increasingly impacting medical care.
  • Pharmacogenetics (PGx) traditionally focused on simple phenotypes like drug levels.
  • Advances in genetic technologies have significantly broadened PGx research scope.

Purpose of the Study:

  • To highlight the expanding role of pharmacogenetics in drug discovery and development.
  • To demonstrate how PGx data can inform clinical development strategies and success rates.
  • To underscore the benefits of PGx for pharmaceutical companies and patient outcomes.

Main Methods:

  • Review of recent pharmacogenetic data and technological advancements.
  • Analysis of the impact of genetic information on drug efficacy and safety studies.

Related Experiment Videos

  • Evaluation of PGx applications in dose selection and therapeutic strategy.

    • Main Results:

    • PGx efficacy and safety studies now impact a broad spectrum of drug discovery and development.
    • Recent PGx data demonstrate applicability to dose selection, efficacy, and safety.
    • Genetic insights offer opportunities to improve clinical development approaches.

    Conclusions:

    • Pharmacogenetics is crucial for personalized medicine, optimizing drug therapy.
    • Advancements in PGx enhance drug development efficiency and success probability.
    • The integration of PGx benefits both pharmaceutical innovation and patient care.