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Related Experiment Videos

Will admixture mapping work to find disease genes?

David Reich1, Nick Patterson

  • 1Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.usa

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 13, 2005
PubMed
Summary

Admixture mapping offers a practical approach for whole-genome association scans to identify common disease risk factors. Further high-powered studies are needed to confirm its utility in localizing disease genes.

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Area of Science:

  • Genetics
  • Population Genetics
  • Disease Gene Discovery

Background:

  • Admixture mapping is an emerging technique for whole-genome association scans.
  • It holds promise for identifying genetic risk factors associated with common diseases.

Purpose of the Study:

  • To evaluate the practical utility of admixture mapping for localizing disease genes.
  • To propose stringent criteria for declaring statistically significant admixture associations with disease.

Main Methods:

  • Whole-genome association scanning using admixture mapping.
  • Analysis of genetic data from admixed populations.

Main Results:

  • Admixture mapping is the first experimentally practical method for genome-wide association studies.

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  • The method is promising for detecting common disease risk factors.

    • Conclusions:

    • Aggressively testing admixture mapping in at least three high-powered studies is recommended.
    • A stringent set of criteria should be adopted for declaring significant admixture associations with disease.