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Related Experiment Videos

Hormone replacement therapy and breast density changes.

J Harvey1, C Scheurer, F T Kawakami

  • 1University of Virginia Health System, Charlottesville, VA, USA.

Climacteric : the Journal of the International Menopause Society
|August 13, 2005
PubMed
Summary
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Transdermal hormone replacement therapy (HRT) significantly reduces breast density and tenderness compared to oral HRT. This study found fewer women on transdermal HRT experienced increased mammographic breast density or breast tenderness.

Area of Science:

  • Endocrinology
  • Gynecology
  • Radiology

Background:

  • Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
  • Both oral and transdermal routes of HRT administration are available.
  • Concerns exist regarding potential side effects of HRT, including changes in breast tissue.

Purpose of the Study:

  • To compare the incidence of increased breast density and tenderness in postmenopausal women receiving transdermal versus oral hormone replacement therapy (HRT).

Main Methods:

  • A randomized study involving 202 postmenopausal women.
  • Participants were assigned to either transdermal (Estalis/Combipatch) or oral (Kliogest) HRT.
  • Mammograms were analyzed for breast density changes, and breast tenderness was assessed over one year.

Related Experiment Videos

Main Results:

  • Transdermal HRT was associated with significantly lower mean breast density (38.4%) compared to oral HRT (46.9%) at study end (p<0.0001).
  • Fewer women on transdermal HRT experienced increased mammographic breast density or breast tenderness compared to the oral HRT group.
  • Only 4% of transdermal HRT users had a marked increase in breast density (>25%), versus 15.7% of oral HRT users. Breast tenderness was reported by 36.0% of transdermal users vs. 57.6% of oral users (p=0.0002).

Conclusions:

  • Transdermal HRT use is linked to a significantly lower occurrence of increased mammographic breast density and breast tenderness compared to oral HRT.