Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Molecular diagnostics in central nervous system tumors.

Christine E Fuller¹, Arie Perry

¹Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St. Louis, MO, USA. christine.fuller@stjude.org

Advances in Anatomic Pathology

|August 13, 2005

Summary

Accurate diagnosis of central nervous system (CNS) neoplasms is challenging. This review highlights common genetic alterations in CNS tumors, focusing on biomarkers for improved diagnostics and patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinicopathologic characterization of a non-expansile, epilepsy-associated neocortical lesion with BRAF K601E mutation.

Journal of neuropathology and experimental neurology·2026

Same author

Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification.

Nature communications·2026

Same author

Primary intracranial sarcomas in Peruvian children: a high-incidence clinicopathological series from a National Reference Center.

Ecancermedicalscience·2026

Same author

Stratification by Ki-67 Labeling Index Increases Specificity of p16<sup>INK4a</sup> Expression as a Surrogate Marker for CDKN2A Inactivation in Meningioma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026

Same author

Murine modeling of IDH-mutant 1p/19q-codeleted oligodendroglioma reveals genotype specific phenotypes.

bioRxiv : the preprint server for biology·2026

Same author

Long-Term Analysis of NRG Oncology RTOG 0539: A Phase II Trial of Observation for Low-Risk Meningioma and Radiotherapy for Intermediate- and High-Risk Meningioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Area of Science:

Neuropathology
Oncology
Molecular Biology

Background:

Central nervous system (CNS) neoplasms present diagnostic challenges due to varied histology and behavior.
Accurate diagnosis is crucial for effective patient care in neuropathology.
Biomarker identification is a growing area of interest to improve CNS tumor diagnosis.

Purpose of the Study:

To review common genetic alterations in CNS tumors.
To focus on biomarkers currently used or emerging in clinical practice.
To aid in the diagnostic, prognostic, and therapeutic management of CNS tumors.

Main Methods:

Literature review of genetic alterations in CNS tumors.
Focus on biomarkers transitioning into clinical neuropathology.

Related Experiment Videos

Emphasis on molecular mechanisms of tumorigenesis.

Main Results:

Few biomarkers, like 1p/19q testing for oligodendrogliomas, are in routine use.
The field is rapidly evolving with new biomarkers emerging.
Genetic alterations are key to understanding CNS tumor heterogeneity.

Conclusions:

Molecular biomarkers are essential for advancing CNS tumor diagnostics.
Continued research into genetic alterations will improve patient outcomes.
Ancillary molecular testing is becoming integral to neuropathology practice.