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Kininogen changes in the alloxan-diabetic rat.
M L Reis1, R Paschoalato, C H Serra
1Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil.
Agents and Actions. Supplements
|January 1, 1992
Summary
Diabetic rats exhibited elevated T-kininogen and reduced urinary kallikrein. Inflammation also increased T-kininogen, suggesting its role in diabetic changes.
Area of Science:
- Biochemistry
- Physiology
- Endocrinology
Background:
- Diabetes mellitus is characterized by metabolic dysregulation.
- The kinin-kallikrein system plays a role in physiological processes.
- Inflammatory responses can influence kininogen levels.
Purpose of the Study:
- To investigate the impact of diabetes on plasma T-kininogen and urinary kallikrein in rats.
- To explore the relationship between inflammation and T-kininogen levels in diabetic conditions.
Main Methods:
- Induction of diabetes in rats using alloxan.
- Measurement of plasma T-kininogen (total, high molecular weight, and low molecular weight kininogens).
- Quantification of urinary kallikrein levels.
- Induction of inflammation using turpentine.
Main Results:
- Alloxan-induced diabetic rats showed significant increases in plasma T-kininogen.
- A substantial decrease in urinary kallikrein levels was observed in diabetic rats.
- Turpentine-induced inflammation also led to changes in T-kininogen levels.
Conclusions:
- Diabetes significantly alters the kinin-kallikrein system in rats.
- Inflammatory responses may contribute to elevated T-kininogen in diabetic states.
- These findings highlight potential interactions between metabolic and inflammatory pathways.