Related Experiment Video
Updated: Aug 16, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
Major depressive episode with psychotic features induced by pegylated interferon-alpha-2b and ribavirin treatment
Sanjeev Sockalingam1, Ken Balderson
1University of Toronto, Toronto, Ontario, Canada. sanjeevsockalingam@hotmail.com
Abstract:
Recent evidence has demonstrated the efficacy of pegylated interferon-alpha (IFN-alpha) in treating hepatitis C virus infection. Neuropsychiatric complications commonly occur during the course of IFN treatment, with depressive symptoms usually appearing within the first 12 weeks. Few cases of the pegylated interferon-alpha-induced psychosis and depression have been reported compared to standard interferon-alpha therapy. We report the first case of a major depressive episode with psychotic features induced by pegylated IFN-alpha-2b and ribavirin in the last 2 weeks of therapy.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Psychosis: Goals of Pharmacotherapy
Psychosis and Antipsychotic Drugs: Overview
Mania and Antimanic Drugs: Overview
Cryptococcal Meningitis
Antidepressant Drugs: Overview