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Long-term effects of antilipidaemic therapy on left ventricular function in patients with dyslipidaemia: multigated
Emre Entok1, Ahmet Unalir, Yuksel Cavusoglu
1Department of Nuclear Medicine, Osmangazi University Medical Faculty, 26480 Eskişehir, Turkey. e_entok@yahoo.com
Insights
Anti-lipidaemic therapy significantly improves cardiac function in patients with dyslipidaemia. Multigated radionuclide ventriculography effectively monitors these improvements in left ventricular systolic and diastolic functions.
Area of Science:
- Cardiology
- Pharmacology
- Medical Imaging
Background:
- Dyslipidaemia adversely affects left ventricular systolic (LVs) and diastolic (LVd) functions, independent of its atherogenic impact in coronary artery disease.
- Patients with dyslipidaemia and preserved left ventricular function often exhibit subclinical cardiac dysfunction.
Purpose of the Study:
- To assess the impact of anti-lipidaemic therapy on LVs and LVd functions.
- To evaluate the efficacy of multigated radionuclide ventriculography (RNV) in monitoring these functional changes.
Main Methods:
- Eighteen patients with dyslipidaemia (LDL > 160 mg/dL) and preserved left ventricular function were enrolled.
- Exclusion criteria included conditions affecting left ventricular function (e.g., coronary artery disease, hypertension, diabetes).
- Multigated radionuclide ventriculography (RNV) was used to measure parameters including ejection fraction, peak ejection rate (PER), and peak filling rate (PFR).
Main Results:
- Statin therapy led to significant reductions in low-density lipoprotein (LDL) and increases in high-density lipoprotein (HDL) levels.
- Key systolic parameters, including PER and aER, showed significant improvement, while TPER decreased.
- Diastolic function parameter, aFF, also significantly increased post-therapy.
Conclusions:
- Anti-lipidaemic therapy demonstrates efficacy in improving cardiac function in dyslipidaemic individuals.
- RNV serves as a valuable non-invasive tool for tracking ventricular function changes during anti-lipidaemic treatment.
Aim:
It has been reported that dyslipidaemia impairs left ventricular systolic (LVs) and diastolic (LVd) functions, irrespective of atherogenic effects, in the setting of coronary artery disease. The aim of the present study was to evaluate the effects of anti-lipidaemic therapy on LVs and LVd functions by means of multigated radionuclide ventriculography (RNV) in subjects with signs of dyslipidaemia and with preserved left ventricular function.
Methods:
Eighteen patients with dyslipidaemia (eight men, 10 women, mean age 50+/-10 years) were included in the study. While the clinical examination and treadmill exercise test results were normal in all patients, low-density lipoprotein levels exceeded 160 mg . dl. Patients with medical conditions including coronary artery disease, hypertension, diabetes, cardiomyopathy and valvular heart disease which would influence left ventricular function were excluded from the study. RNV was performed in all subjects, taking into account the best septal position to differentiate the left ventricle from the right ventricle. The following parameters were calculated: ejection fraction, peak ejection rate (PER), time to peak ejection (TPER), a ejection rate (aER), a ejection fraction (aEF), Peak filling rate (PFR), time to peak filling rate (TPFR), a filling rate (aFR), a filling fraction (aFF).
Results:
The low-density lipoprotein value decreased and the high-density lipoprotein value increased after statin therapy (P<0.001 and P<0.003, respectively). PER, aER and aFF significantly increased and TPER decreased as a consequence of statin therapy (respectively, P<0.05, P<0.05, P<0.05 P<0.05).
Conclusion:
Anti-lipidaemic therapy is effective in dyslipidaemic patients. RNV is a useful and non-invasive method for monitoring changes in ventricular function following anti-lipidaemic treatment strategies.
