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Omeprazole-induced hepatitis.

Wael El-Matary¹, Mark Dalzell

¹Gastroenterology Unit, Royal Liverpool Children's NHS Trust, UK. welmatary@yahoo.com

Pediatric Emergency Care

|August 13, 2005

Summary

This summary is machine-generated.

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Proton pump inhibitor omeprazole is generally safe, but can cause liver damage. This case report highlights omeprazole-induced hepatitis in a child, a rare but serious side effect.

Area of Science:

Hepatology
Pediatric Gastroenterology
Pharmacology

Background:

Omeprazole, a widely used proton pump inhibitor (PPI), is effective for gastro-esophageal reflux and peptic ulcer disease.
Its safety and efficacy are well-documented in numerous clinical trials.
However, omeprazole-related hepatotoxicity is less recognized, particularly in pediatric patients.

Observation:

This report details a case of a child who developed hepatitis after taking omeprazole.
The child's presentation and clinical course are described.

Findings:

The patient experienced liver injury attributed to omeprazole intake.
This represents a potential adverse drug reaction in the pediatric population.

Implications:

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This case underscores the importance of considering omeprazole-induced hepatitis in children presenting with liver dysfunction.
Further investigation into the incidence and mechanisms of PPI-induced hepatotoxicity in pediatric populations is warranted.
Clinicians should be vigilant for potential liver injury when prescribing omeprazole to children.