[Role of proteoglycans and glycosaminoglycans in the intervertebral disc degeneration]
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Updated: Aug 16, 2026

Optical Sectioning and Visualization of the Intervertebral Disc from Embryonic Development to Degeneration
Published on: July 8, 2021
Jan Fortuniak1, Dariusz Jaskólski, Krzysztof Tybor
1Klinika Neurochirugii, Uniwersytet Medyczny, ul. Kopcińskiego 22, 90-153 Łódź. jfort@esculap.pl
Abstract:
Proteoglycans and glycosaminoglycans are the main components of the extracellular matrix of the nucleus pulposus. Intervertebral disc degeneration due to aging and excessive mechanical loads results in adverse quantitative and structural changes to the macromolecules. Metalloproteinases induced by inflammatory mediators play a key role in degrading proteoglycans. Progressive matrix breakdown decreases water content in the disc. Dehydration compromises disc cells function and impairs resistance to compression. Biochemical changes may result in disc prolapse. Modifying the metabolism of proteoglycans and glycosaminoglycans might be an effective therapeutic strategy.
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Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Proteoglycans
Matrix Proteoglycans and Glycoproteins

