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Updated: Aug 16, 2026

Partial Heterotopic Hindlimb Transplantation Model in Rats
Published on: June 9, 2021
Successful replantation of the leg in a pre-ambulatory infant
Neil F Jones1, Eon K Shin, Amir Mostofi
1UCLA Hand Center, Department of Orthopaedic Surgery, Division of Plastic and Reconstructive Surgery, Los Angeles, California 90095, USA.
Insights
This study details the first successful below-knee amputation replantation in a 7-month-old infant. Seven years post-surgery, the child exhibits excellent function, walking and running without aids, showcasing remarkable pediatric limb replantation success.
Area of Science:
- Pediatric Orthopedics
- Reconstructive Surgery
- Traumatology
Background:
- Limb replantation in infants presents unique challenges due to rapid growth and developmental plasticity.
- Below-knee amputations in very young children require specialized surgical approaches to optimize long-term function.
Purpose of the Study:
- To document the long-term functional outcomes of a below-knee amputation replantation in a 7-month-old infant.
- To evaluate the potential for spontaneous correction of limb length discrepancy in pediatric replantation.
- To highlight the benefits of early intervention in pediatric limb trauma.
Main Methods:
- Successful surgical replantation of a traumatically amputated below-knee limb in a 7-month-old infant.
- Long-term clinical follow-up over seven years, assessing range of motion, sensation, and functional mobility.
- Radiographic evaluation of limb length discrepancy.
Main Results:
- The child demonstrates excellent ankle and knee range of motion and regained plantar sensation.
- The patient can walk, run, and jump without assistive devices.
- A 5.5 cm leg-length discrepancy is present but expected to improve with future bone overgrowth.
Conclusions:
- Early below-knee replantation in infancy can lead to excellent functional recovery and near-normal gait.
- The plasticity of the pediatric central nervous system and skeletal system supports successful long-term outcomes.
- This case underscores the viability of limb replantation in very young children, even prior to ambulation.
Abstract:
The authors report the first successful replantation of a below-knee amputation in a 7-month-old infant prior to the development of a standing and walking gait. Seven years following surgery, the child demonstrates excellent ankle and knee range of motion, has regained plantar sensation, and is able to walk, run, and jump without needing a brace. Despite a leg-length discrepancy of 5.5 cm, it is likely that future overgrowth of the injured limb will improve this discrepancy. This child has excellent potential for a successful functional outcome, given the very young age at the time of replantation and the plasticity of the central nervous system.

