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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
[Indication and strategy of on-pump coronary artery bypass grafting in elderly patients]
1Department of Cardiovascular Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
Insights
On-pump coronary artery bypass grafting (CABG) is safe for elderly patients. Careful management of procedures ensures positive outcomes, even for those over 80 years old.
Area of Science:
- Cardiology
- Geriatric Medicine
- Cardiothoracic Surgery
Background:
- Increasing elderly population necessitates evaluation of surgical risks.
- Coronary artery bypass grafting (CABG) in older adults requires careful risk assessment.
Purpose of the Study:
- To assess the safety and outcomes of on-pump CABG in elderly patients (≥70 and ≥80 years).
- To compare the risks and complications of on-pump CABG between elderly and younger patient cohorts.
Main Methods:
- Retrospective analysis of 12 patients aged ≥80 undergoing on-pump CABG, compared to 1,988 younger patients.
- Comparison of 341 patients aged ≥70 with 1,659 younger patients undergoing on-pump CABG.
- Evaluation of pre- and postoperative factors, including mortality and complications.
Main Results:
- No in-hospital mortality or postoperative complications observed in the 12-patient group (≥80 years).
- Elderly patients (≥70 years) were more severely ill preoperatively but had similar postoperative complication rates compared to younger patients.
- Higher in-hospital mortality observed in the elderly group (≥70 years) despite similar complication rates.
Conclusions:
- On-pump CABG can be performed safely in elderly patients, including those ≥80 years, with meticulous pre-, intra-, and postoperative management.
- While risks are higher in older adults, careful surgical planning mitigates adverse outcomes.
- On-pump CABG remains a viable option for elderly patients with coronary artery disease.
Abstract:
As elderly people are increasing nowadays, so is coronary artery bypass grafting (CABG) for these older patients. The risk of on-pump CABG for elderly patients is thought to be higher than that for younger patients. We assessed 12 patients, 80 years of age or older, who underwent on-pump CABG, and compared them with 1,988 patients younger than 80 years old. In the elderly patient group, there were no in-hospital mortality and no postoperative complications. There was no statistical difference in the pre- and postoperative factors between the 2 groups except for the cardiopulmonary bypass time. We also compared the pre- and postoperative factors of 341 patients, 70 years of age or older, who underwent on-pump CABG with those of 1,659 patients under 70 years of age. The preoperative factors of elderly patients indicated that they were more severely ill than younger patients. In the analysis of postoperative factors, the rate of postoperative complications were similar between the 2 groups, despite the significantly higher rate of in-hospital mortality in the elderly group. The risk of on-pump CABG for elderly patients is higher than that for younger patients, but with careful management of the pre-, intra-, and postoperative procedures, we can perform on-pump CABG safely even in the elderly patients.
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