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Related Experiment Videos

Apparent CBF decrease with normal aging due to partial volume effects: MR-based partial volume correction on CBF

Kentaro Inoue1, Hiroshi Ito, Ryoi Goto

  • 1Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan. kenta@idac.tohoku.ac.jp

Annals of Nuclear Medicine
|August 16, 2005
PubMed
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Age-related changes in cerebral blood flow (CBF) may reflect gray matter morphology differences. Partial volume correction (PVC) using MRI data refined CBF analysis in healthy subjects.

Area of Science:

  • Neuroimaging
  • Cerebrovascular Physiology
  • Gerontology

Background:

  • Previous single photon emission tomography (SPECT) studies indicate age and gender influence cerebral blood flow (CBF).
  • Partial volume effects (PVE) are a potential confound in SPECT-based CBF measurements.
  • Magnetic resonance (MR) imaging offers higher spatial resolution for PVE correction.

Purpose of the Study:

  • To investigate the impact of aging and gender on CBF using SPECT.
  • To evaluate the effectiveness of partial volume correction (PVC) using MR imaging.
  • To determine if observed age-related CBF changes are linked to gray matter morphology.

Main Methods:

  • Utilized 99mTc-ethyl cysteinate dimer SPECT and MR imaging in 44 healthy adults (29 males, 15 females).

Related Experiment Videos

  • Performed MR image segmentation and coregistration with SPECT for PVC.
  • Applied SPM99 for statistical analysis of age and gender effects on CBF, before and after PVC.

    • Main Results:

    • Age-related decreases in CBF were initially observed in the prefrontal cortex, lateral sulcus, and lateral ventricles.
    • After PVC, the prefrontal cortex CBF decrease lost statistical significance.
    • Significant age-related CBF decreases persisted along the lateral sulcus and ventricle, potentially due to morphological changes (dilatation) not fully corrected by spatial normalization.

    Conclusions:

    • Age effects on CBF in healthy individuals may be influenced by age-related morphological changes in gray matter.
    • PVC using MR imaging is crucial for accurate CBF assessment, particularly in regions susceptible to PVE.
    • Spatial normalization alone may not fully account for age-related structural brain changes impacting CBF interpretation.