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Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Disulfide bond cleavage induced by a platinum(II) methionine complex

Haiying Wei1, Xiaoyong Wang, Qin Liu

  • 1State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, 210093 Nanjing, PR China.

Inorganic Chemistry
|August 16, 2005
PubMed
Summary

A platinum(II) complex, [Pt(Met)Cl2], effectively cleaves disulfide bonds in oxidized glutathione (GSSG). This reaction is significantly faster than with cisplatin, offering insights into platinum complexes within cellular redox systems.

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