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Updated: Aug 10, 2026

Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Cell cycle: proteomics gives it a spin
1Department of Genetics, University of Cambridge, Downing Street, CB2 3EH, UK. va228@mole.bio.cam.ac.uk
Abstract:
The eukaryotic cell division cycle has been studied at the molecular level for over 30 years, most fruitfully in model organisms. In the past 5 years, developments in mass spectrometry-based proteomics have been applied to the study of protein interactions and post-translational modifications involving key cell cycle regulators such as cyclin-dependent kinases and the anaphase-promoting complex, as well as effectors such as centrosomes, the kinetochore and DNA replication forks. In addition, innovations in chemical biology, functional proteomics and bioinformatics have been employed to study the cell cycle at the proteome level. This review surveys the contributions of proteomics to cell cycle research. The near future should see the application of more quantitative proteomic approaches to probe the dynamic aspects of the molecular system that underlie the cell cycle in model organisms and in human cells.
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