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Updated: Aug 16, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
Memory T cell homeostasis and senescence during aging
Arne N Akbar1, Jean M Fletcher
1Department of Immunology and Molecular Pathology, Division of Infection and Immunity, University College London, UK. aakbar@ucl.ac.uk
Abstract:
Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are driven to exhaustion in elderly subjects, a pertinent point in view of increasing human life expectancy. An emerging consensus is that cytomegalovirus (CMV), a beta-herpesvirus with a prevalence of 60-90% worldwide, is an agent that induces specific T cells to extreme differentiation. The question that begs to be answered is whether this can explain why CMV seropositivity and the presence of highly differentiated CMV-specific T cells are included in a cluster of immune parameters that have been shown recently to predict the early mortality of elderly humans.
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