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Common use of inaccurate antibody assays to identify infection status with herpes simplex virus type 2
Rhoda Ashley Morrow1, Zane A Brown
1Laboratory Medicine, University of Washington School of Medicine, Seattle 98195, USA.
Abstract:
In recent proficiency testing of herpes simplex virus type-specific serologic evidence by the College of American Pathologists, commercially available herpes simplex virus antibody assays that were not glycoprotein-G based demonstrated high false-positive rates (14%-88%) for herpes simplex virus type-2 antibodies in sera that were positive for herpes simplex virus type-1 antibodies but negative for herpes simplex virus type-2 antibodies. Herpes simplex virus serologic testing should be performed with only glycoprotein-G-based tests.
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