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Ozone therapy effects on biomarkers and lung function in asthma
Frank A Hernández Rosales1, José L Calunga Fernández, José Turrent Figueras
1Departmento de Biomedicina, Centro de Investigaciones del Ozono del Centro Nacional de Investigaciones Científicas, Ciudad de la Habana, Cuba. frank.hernandez@cnic.edu.cu
Archives of Medical Research
|August 16, 2005
Summary
Systemic ozone therapy effectively reduced immunoglobulin E (IgE) and inflammatory markers while boosting antioxidant pathways in asthma patients. Ozone major autohemotherapy (MAHT) showed superior results compared to rectal insufflations (RI).
Area of Science:
- Immunology
- Respiratory Medicine
- Oxidative Stress Research
Background:
- The interplay between serum immunoglobulin E (IgE), human leukocyte antigen DR (HLA-DR) expression on peripheral blood mononuclear cells (PBMC), and erythrocyte glutathione antioxidant pathways in asthma patients undergoing systemic ozone therapy remains uninvestigated.
- Atopic asthma is often associated with oxidative stress, indicated by reduced glutathione antioxidant parameters prior to treatment.
Purpose of the Study:
- To investigate the effects of systemic ozone therapy on IgE levels, HLA-DR expression, and antioxidant biomarkers in asthma patients.
- To compare the efficacy of different ozone therapy protocols, including ozone major autohemotherapy (MAHT) and ozone rectal insufflations (RI).
Main Methods:
- Asthma patients received approximately one year of ozone therapy across three cycles, utilizing MAHT (4 and 8 mg doses) or RI (10 mg dose).
- Serum IgE, PBMC HLA-DR expression, and erythrocyte glutathione pathway biomarkers were measured pre- and post-treatment cycles.
- Pulmonary function and symptom scores were assessed at baseline and after the third cycle.
Main Results:
- All ozone therapy protocols led to decreased IgE and HLA-DR levels, alongside increased reduced glutathione, glutathione peroxidase, glutathione reductase, and glutathione S-transferase.
- Significant improvements in lung function and asthma symptoms were observed.
- The efficacy order was MAHT at 8 mg > MAHT at 4 mg > RI at 10 mg for all measured parameters.
Conclusions:
- Systemic ozone therapy demonstrates efficacy in asthma management by reducing IgE and inflammatory mediators while enhancing antioxidant capacity.
- Ozone therapy exhibits immunomodulatory effects and regulates oxidative stress in atopic asthma, suggesting its therapeutic potential.