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Related Experiment Videos

Sub-optimal fetal iron acquisition under a maternal environment.

Jose C Jaime-Perez1, Jose L Herrera-Garza, David Gomez-Almaguer

  • 1Department of Hematology, School of Medicine and University Hospital Dr. Jose E. Gonzalez, Autonomous University of Nuevo Leon, Monterrey, Mexico. carjaime@hotmail.com

Archives of Medical Research
|August 16, 2005
PubMed
Summary

Maternal iron deficiency in urban disadvantaged women significantly impacts newborn iron stores, highlighting a need for early intervention trials to support infant development.

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Area of Science:

  • Perinatal Medicine
  • Nutritional Science
  • Public Health

Background:

  • Early-life iron deficiency can cause developmental issues.
  • Assessing iron reserves in neonates from disadvantaged urban populations is crucial.
  • Understanding maternal iron's influence on neonatal outcomes is vital.

Purpose of the Study:

  • To determine iron reserves in neonates born to urban disadvantaged women.
  • To analyze the impact of maternal iron status on newborn hemoglobin, birth weight, and height.
  • To evaluate the necessity of an interventional trial for this population.

Main Methods:

  • Measured hemoglobin and serum ferritin (SF) in 201 neonates and their mothers at delivery.
  • Classified neonatal and maternal iron stores using SF concentration cut-offs (<12.0 microg/L deficient, 12.0-29.9 microg/L reduced, >=30 microg/L replenished).

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  • Analyzed correlations between maternal and neonatal iron stores and neonatal anthropometrics.

    • Main Results:

    • 86% of neonates had normal iron stores (SF >= 30 microg/L), but 6.5% were deficient (SF < 12.0 microg/L) and 7.5% had reduced stores (SF 12.0-29.9 microg/L).
    • Neonatal iron stores were reduced when maternal iron stores were deficient.
    • No significant differences in cord hemoglobin, birth weight, or height were observed across iron store groups.

    Conclusions:

    • Maternal iron deficiency limits fetal iron acquisition and reserve constitution.
    • Findings support the need for an interventional trial to address iron deficiency in this population.
    • Gestational iron deficiency negatively impacts fetal iron reserves, independent of birth weight, height, or hemoglobin.