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Updated: Aug 16, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Mammalian cadherins and protocadherins: about cell death, synapses and processing
Dirk Junghans1, Ingrid G Haas, Rolf Kemler
1Max-Planck Institute of Immunobiology, Dept. of Molecular Embryology, 79108 Freiburg, Germany.
Abstract:
Cadherins have been known for a long time to be key elements in many important biological processes. In particular, the role of classical cadherins in mediating adhesion has been examined in great detail. Over recent years, the accumulation of experimental tools and mice mutants has allowed more refined analysis of cadherin functions, and new aspects such as signaling and synapse dynamics have become the center of interest. In addition, the study of mice lacking the entire protocadherin-gamma cluster shed the first light on a possible novel function of members of this cadherin family in synapse formation and cell survival during development.
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