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Updated: Aug 16, 2026
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Production of the radioactive antitumoral cisplatin
Alexandre S Leal1, Alvaro D Carvalho Júnior, Fabiana M Abrantes
1Division for Radiation Technology, Nuclear Technology Development Centre (CDTN)/National Commission for Nuclear Energy (CNEN), P.O. Box 941, CEP 30123-970, Belo Horizonte, Minas Gerais, Brazil. asleal@sdtn.br
Abstract:
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
