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Barbiturates and calcium-activated adenosine triphosphatase.

M Willow, G A Johnston

    Neuroscience Letters
    |October 1, 1979
    PubMed
    Summary

    Different barbiturates have opposing effects on brain cell calcium activity. Anesthetic barbiturates enhance calcium-activated adenosine triphosphatase, while convulsant barbiturates inhibit it, impacting neurotransmitter release.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Biochemistry

    Background:

    • Barbiturates are drugs with diverse central nervous system effects.
    • Calcium-activated adenosine triphosphatase (Ca-ATPase) plays a crucial role in neuronal function.
    • Differential effects of barbiturate classes on neuronal mechanisms are not fully understood.

    Purpose of the Study:

    • To investigate the distinct effects of anesthetic and convulsant barbiturates on Ca-ATPase activity in rat brain synaptosomes.
    • To explore the relationship between Ca-ATPase modulation and neurotransmitter release.

    Main Methods:

    • Preparation of rat brain synaptosomes.
    • Assay of Ca-ATPase activity in the presence of anesthetic and convulsant barbiturates.
    • Analysis of potential modifications in neurotransmitter release.

    Main Results:

    • Anesthetic barbiturates significantly potentiated Ca-ATPase activity.
    • Convulsant barbiturates significantly inhibited Ca-ATPase activity.
    • These differential effects suggest a mechanism for varied in vivo actions.

    Conclusions:

    • Barbiturates exhibit opposing effects on neuronal Ca-ATPase activity.
    • Modulation of Ca-ATPase by barbiturates may underlie their distinct anesthetic and convulsant properties.
    • Further research is warranted to elucidate the in vivo implications for neurotransmission.

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