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Related Experiment Videos

Indigo carmine for the selective endoscopic intervertebral nuclectomy.

Inn-Se Kim1, Kyung-Hoon Kim, Sang-Wook Shin

  • 1Department of Anesthesia and Pain Medicine, College of Medicine, Pusan National University, Busan, Korea.

Journal of Korean Medical Science
|August 16, 2005
PubMed
Summary

Indigo carmine dye selectively stains degenerated nucleus pulposus during endoscopic discectomy. This allows for precise removal of damaged disc tissue, improving surgical outcomes for herniated discs.

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Correction: Yoon et al. Black Wheat Extracts (Arriheuk) Regulate Adipogenesis and Lipolysis via Adenosine Monophosphate (AMP) Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Signaling Pathways. <i>Foods</i> 2023, <i>12</i>, 2727.

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Area of Science:

  • Spine surgery
  • Intervertebral disc degeneration
  • Surgical navigation

Background:

  • Intervertebral disc herniation is a common cause of back pain.
  • Accurate identification of degenerated disc tissue is crucial for effective surgical treatment.
  • Current methods may lack precision in distinguishing between healthy and degenerated nucleus pulposus.

Purpose of the Study:

  • To validate indigo carmine as a selective marker for degenerated nucleus pulposus.
  • To assess the efficacy of indigo carmine in guiding endoscopic discectomy.
  • To differentiate between normal and degenerated disc tissue during surgery.

Main Methods:

  • Endoscopic discectomy was performed on 5 patients with herniated discs.
  • Discography was conducted using a mixture of indigo carmine and radioactive dye.

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  • Discolored (infiltrated) and undiscolored (control) tissue samples were microscopically analyzed.

    • Main Results:

    • Indigo carmine successfully stained degenerated nucleus pulposus.
    • Microscopic analysis revealed collagen fiber destruction and vascular/nerve ingrowth in stained areas.
    • Undiscolored tissue represented normal nucleus pulposus with intact collagen type II and aggrecan.

    Conclusions:

    • Indigo carmine effectively identifies degenerated nucleus pulposus.
    • This technique enables selective removal of diseased disc tissue during endoscopic discectomy.
    • Indigo carmine enhances precision in treating intervertebral disc herniation.