Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cytochrome P4502E1. Polymorphism, physiological function, regulation, and role in pathology].

O O Pentiuk, S O Kachula, O Kh Herych

    Ukrains'Kyi Biokhimichnyi Zhurnal (1999 )
    |August 17, 2005
    PubMed
    Summary

    Cytochrome P450 2E1 (CYP2E1) is crucial for metabolizing various substances, including toxins and endogenous compounds. Its altered activity in conditions like diabetes and alcoholism can increase xenobiotic toxicity, but inhibitors show hepatoprotective effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Activity of hydrogen sulfide production enzymes in kidneys of rats].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2010
    Same author

    [Influence of hydrogen sulfide, dithionite, sulfite, thiosulfate and sulfate anions on human platelet aggregation].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2009
    Same author

    [Effect of diet overloaded by fats on the enzyme systems of metabolism in rats].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2008
    Same author

    [Effect of homocysteine, cysteine, and their derivatives on the platelet link of hemostasis system].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2008
    Same author

    Age-related effects of methionine-enriched diet on plasma homocysteine concentration and methylation of hepatic DNA in rats.

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2006
    Same author

    [Effect of starvation and acetone on the enzyme systems of biotransformation and toxicity of xenobiotics--CYP2E1 substrates in rats].

    Ukrains'kyi biokhimichnyi zhurnal (1999 )·2005

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Toxicology

    Context:

    • Cytochrome P450 2E1 (CYP2E1) plays a significant role in the metabolism of both endogenous and exogenous compounds.
    • Understanding CYP2E1's function is vital due to its involvement in the biotransformation of numerous drugs and environmental toxins.
    • Polymorphisms in the CYP2E1 gene can influence individual susceptibility to toxic effects.

    Purpose:

    • To review the multifaceted role of Cytochrome P450 2E1 in substance metabolism.
    • To explore the regulation of CYP2E1 expression and its activity changes in pathological conditions.
    • To highlight the implications of CYP2E1 activity on xenobiotic toxicity and potential therapeutic interventions.

    Summary:

    • CYP2E1 catalyzes key reactions, including the initial steps of acetone metabolism, ethanol oxidation, and fatty acid hydroperoxide breakdown.

    Related Experiment Videos

  • Metabolism of xenobiotics by CYP2E1 often generates toxic intermediates and reactive oxygen species, contributing to cellular damage.
  • Regulation involves transcriptional control and substrate-induced stabilization, with increased activity observed in alcoholism, diabetes, obesity, and steatohepatitis.

    • Impact:

    • Elevated CYP2E1 activity exacerbates the toxicity of xenobiotics like paracetamol, halothane, benzene, and carbon tetrachloride.
    • Inhibitors of CYP2E1, such as diallyl sulfide and disulfiram, demonstrate significant hepatoprotective properties.
    • This review underscores the therapeutic potential of modulating CYP2E1 activity for managing toxic exposures and related diseases.