Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent advances in analytical construct resins.

D M Whitehead1, S C McKeown, A Routledge

  • 1Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.

Combinatorial Chemistry & High Throughput Screening
|August 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary intake estimate for perfluorooctanesulphonic acid (PFOS) and other perfluorocompounds (PFCs) in UK retail foods following determination using standard addition LC-MS/MS.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment·2010
Same author

Single bead characterization using analytical constructs: application to quality control of libraries.

Analytical chemistry·2001
Same author

Solid-phase reaction monitoring--chemical derivatization and off-bead analysis.

Biotechnology and bioengineering·2001
Same author

The glycosidic precursor of (Z)-5-ethylidene-2(5H)-furanone in Halocarpus biformis juvenile foliage.

Phytochemistry·1996
Same author

Relationship between hepatic fatty acid oxidation and gluconeogenesis in the fasting neonatal pig.

The British journal of nutrition·1993
Same author

Effect of colostrum intake on hepatic gluconeogenesis and fatty acid oxidation in the neonatal pig.

Journal of animal science·1991
Same journal

Exploring Spectral Graph Theory in Combinatorial Chemistry.

Combinatorial chemistry & high throughput screening·2026
Same journal

Unveiling the Cellular and Molecular Insights into Ulcerative Colitis Pathogenesis through Integrative Multi-omics and Functional Experiments.

Combinatorial chemistry & high throughput screening·2026
Same journal

Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

Combinatorial chemistry & high throughput screening·2026
Same journal

Exploration and Prospects of Core Research Hotspots in the Mechanisms of Traditional Chinese Medicine for Treating Digestive System Malignancies Based on Bibliometrics.

Combinatorial chemistry & high throughput screening·2026
Same journal

Investigating the Potential Pharmacological Mechanisms of Huangqi in Allergic Rhinitis Using Network Pharmacology and Molecular Docking Strategies.

Combinatorial chemistry & high throughput screening·2026
Same journal

DNMT3A-driven Clonal Expansion of Hematopoiesis Influences Autoimmunity Mediated by Distinct Immune Cell Populations: A Mendelian Randomization Study.

Combinatorial chemistry & high throughput screening·2026
See all related articles

Analytical construct resins offer a solution to monitoring challenges in solid-phase synthesis. This technology enables quality control and the development of new synthetic sequences on solid supports.

Area of Science:

  • Solid-phase synthesis
  • Analytical chemistry
  • Combinatorial chemistry

Background:

  • Solid-phase synthesis has grown significantly, but analyzing resin-bound reactions is difficult due to limited analytical methods.
  • Traditional monitoring requires cleaving the substrate from the solid support, creating an 'analytical bottleneck'.

Purpose of the Study:

  • To review the development and applications of analytical construct resins.
  • To highlight recent advancements in this technology for solid-phase synthesis.

Main Methods:

  • Elaboration of Merrifield's dual linker strategy by Geysen in 1996.
  • Incorporation of an encoding system between two in-line linkers on resins.
  • Utilizing analytical construct resins for quality control and synthetic sequence development.

Related Experiment Videos

Main Results:

  • Analytical construct resins provide a novel approach for monitoring resin-bound reactions.
  • This technology facilitates quality control of combinatorial libraries.
  • It aids in the development of new synthetic sequences on solid supports.

Conclusions:

  • Analytical construct resins effectively address the limitations in analyzing solid-phase synthesis.
  • The technology is valuable for both quality assurance and synthetic innovation.
  • Recent applications demonstrate the expanding utility of analytical construct resins.