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Published on: January 3, 2013
Adjusted carbohydrate antigen 19-9. Correlation with histological grade in pancreatic adenocarcinoma
Jorge Ortiz-González1, Nora Patricia Alvarez-Aguila, Juan Manuel Medina-Castro
1Department of Surgical Oncology, National Institute of Cancerology, México DF, México. ortizgj_p@correo.unam.mx
Background:
The serum level of carbohydrate antigen 19-9 (CA 19-9) depends on the tumor size and differentiation grade. Jaundice can cause an elevation of serum CA 19-9, although the nature of this interaction is not fully understood.
Patients And Methods:
This was a retrospective study of 26 patients with potentially resectable pancreatic adenocarcinoma. Serum CA 19-9 was correlated with the histological differentiation. CA 19-9 adjusted for serum bilirubin was determined and analyzed.
Results:
No correlation between CA 19-9 and histological differentiation was determined (p>0.05). The median adjusted CA 19-9 level was significantly lower (p=0.01) in patients with normal biliary excretion than those with bilirubin levels >2 mg/dL.
Conclusion:
These data are consonant with the theory of a dual contribution to the serum CA 19-9 level from biliary obstruction and tumor cell synthesis.
