Related Experiment Video
Updated: Aug 16, 2026

Single Port Donor Nephrectomy
Published on: March 12, 2011
Donors of HNO
Katrina M Miranda1, Herbert T Nagasawa, John P Toscano
1Department of Chemistry, University of Arizona, Tucson, 85721, USA. kmiranda@email.arizona.edu
Abstract:
Recent comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. Although the mechanisms of action are currently unresolved, the pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke. This review provides a detailed discussion of the most commonly utilized donors of HNO as well as a guideline for the characterization of novel donors.
Related Concept Videos
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by water loss...
Kidney Transplant I: Introduction
Kidney Transplant II: Surgical Procedure
2° Amines to N-Nitrosamines: Reaction with NaNO2
Aldehydes and Ketones with HCN: Cyanohydrin Formation Mechanism

