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Updated: Jul 21, 2026
07:03
Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration
Published on: May 4, 2017
Control of eosinophil toxicity in the lung
G M Walsh1, M Al-Rabia, M G Blaylock
1Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK. g.m.walsh@abdn.ac.uk
Current Drug Targets. Inflammation and Allergy
|August 17, 2005
Summary
Eosinophils contribute to asthma pathogenesis. Strategies to limit eosinophil toxicity, including new drug developments and immune modulation, are crucial for treating allergic diseases.
Area of Science:
- Immunology
- Pulmonology
- Allergy
Background:
- Eosinophils drive asthma and allergic disease pathogenesis through pro-inflammatory mediator release.
- Eosinophils influence immune responses within the asthmatic lung.
- Understanding eosinophil accumulation mechanisms is key to developing targeted therapies.
Purpose of the Study:
- To review current strategies for limiting eosinophil-induced toxicity in asthma.
- To discuss potential advancements in therapeutic approaches targeting eosinophils.
- To evaluate the efficacy and limitations of various anti-eosinophil strategies.
Main Methods:
- Review of existing literature on eosinophil biology and asthma.
- Analysis of therapeutic targets including glucocorticoids, monoclonal antibodies (anti-IL-4, IL-13, IL-5), adhesion pathways, and chemokines.
- Exploration of apoptosis induction and phagocytosis for eosinophil clearance.
Main Results:
- Eosinophil accumulation involves complex mechanisms: bone marrow release, adhesion, migration, chemotaxis, and delayed apoptosis.
- Glucocorticoid (GC) development aims to separate anti-inflammatory effects from side effects.
- Monoclonal antibodies and pathway inhibitors offer targeted approaches to reduce eosinophil presence.
Conclusions:
- Multiple points exist to intervene and limit eosinophil toxicity in asthma.
- Targeting eosinophil-specific pathways holds promise for improved asthma management.
- Further research is needed to optimize therapies for safe and effective eosinophil removal.
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